Endocrine Abstracts

The treatment of orbitopathy in the course of Graves’ disease (GO, Graves’ Orbitopathy) still remains a serious therapeutic challenge. Modification of risk factors is considered to be the most important and the most effective method of treatment of benign GO. Treatment with intravenous glucocorticosteroid preparations remains the first-line therapy for moderate- to severe GO but is insufficient in some patients. Radiotherapy has been used in active GO therapy for d...

Objectives: The objective was to evaluate effects of hyperthyroidism and hypothyroidism on bone metabolism in premenopausal women with special emphasis to osteoprotegerin (OPG) and vitamin D3 (vD).Materials and methods: A total of 119 women aged 18–52 years were studied (38 with recently diagnosed hyperthyroidism; 40 with newly diagnosed hypothyroidism; 41 healthy women as controls). Patients were followed up for a period of 1 year. BMD, ...

Introduction: Peroxisome proliferation-activated receptors-γ (PPAR-γ) have been shown to be involved in adipogenesis as well as in immunoregulation and inflammation control. Orbital fibroblast differentiation to adipocytes is a PPAR-γ dependent process essential for pathogenic tissue remodeling in Graves orbitopathy (GO).Purpose: We studied the occurrence and possible associations of the Pro115Gln and Pro12Ala in the ...

Hyperprolactinemia may lead to bone loss, both due to hypogonadism and other hormonal disturbances.Aim: Aim of the study was the analysis of influences of hormonal profiles associated with hyperprolactinemia on bone mineral density (BMD) and bone turnover in women with hyperprolactinemia of various origin. The subjects were 32 patients with prolactinoma, 43 ones with functional hyperprolactinemia and 29 healthy controls. All of them were studied BMD (lum...

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a B7-binding protein that plays an important role in the down-regulation of T-cell activation. CTLA-4 function is closely associated with predisposition to autoimmune diseases. A native soluble form of CTLA-4 (sCTLA-4) is reported to be present in the sera of patients suffering from autoimmune thyroid disease. In this study we report data on sCTLA-4 concentrations in patients with clinical expression of Graves’ disease.<p c...

Background: Polycystic ovary syndrome (PCOS) is a heterogenous endocrinopathy commonly diagnosed in reproductive age women, predisposing to the development of metabolic disturbances. However, the mechanisms underlying the connection between PCOS and metabolic disorders are still not well understood. The aim of the study was to investigate amino acid (AA) profile in women with PCOS and to assess its relation with metabolic disturbances.Methods: 326 women:...

Objective: The purpose of the study was to investigate osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANK-L) levels in acromegaly patients with regard to the disease activity. The associations between OPG, RANK-L and random growth hormone (GH), insulin-like growth factor 1 (IGF-1), lumbar spine (LS) bone mineral density (BMD), femoral neck (FN) BMD were also evaluated.Methods: A study group included 72 patients with acrom...

Introduction: Sclerostin is well-known as an inhibitor of bone formation but also promotes bone resorption. Acromegaly is a disease characterized by increased bone turnover and higher vertebral fracture risk.Purpose: The aim of the study was to determine sclerostin levels in acromegaly patients with regard to the disease activity. We also evaluated the associations between sclerostin and random growth hormone (GH), insulin-like growth factor 1 (IGF-I), l...

Objectives: Amino acids (AA) plasma profile is associated with cardiometabolic diseases (CMD), predicts diabetes mellitus type 2 (DM2) and cardiovascular diseases (CVD) many years in advance. Metabolic syndrome (MS) defines the area of metabolic disturbances that precede DM2 and CVD development. The primary objective of the study was to examine the association between BCAA (branched chain amino acids), AAA (aromatic amino acids) profile and MS’s phenotype and to evaluate ...

Background: The association between fat mass and obesity-associated gene (FTO) polymorphism rs 9939609 and obesity was found in some European countries. However, the data concerning Polish population is insufficient. The relationship between FTO and metabolic disorders remains unclear.Methods: The study group consisted of 686 women and 418 men from Lower Silesia in Poland, aged 30–80 years (mean age 54.2±9.26 years). The examination included an...